Process for preparing analgesic compounds

Details Process for preparing analgesic compounds Process for preparing analgesic compounds

1995-03-24

1997-08-12

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 60, 544 61, 544 584, 544362, 544364, 544365, 544372, 544376, 544379, 5142282, 546192, 546207, 546226, C07D40314, C07D40306, C07D40106, C07D41706

Patent

active

056567588

ABSTRACT:
A process for preparing a compound of the formula (I): ##STR1## in which, R.sup.1 and R.sup.2 each represents hydrogen or C.sub.1 -C.sub.6 alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a heterocycle; E represents methylene, sulfur, oxygen or imino group optionally substituted with C.sub.1 -C.sub.6 alkyl or aralkyl; ring A is aryl or heteroaryl ring, optionally substituted; R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.4 is hydrogen or R.sup.3 and R.sup.4 together represent a group of formula (IV):

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