Process for preparing an organic synthesis intermediate

Details Process for preparing an organic synthesis intermediate Process for preparing an organic synthesis intermediate

1989-12-20

1991-06-11

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 4545

Patent

active

050233815

ABSTRACT:
A process is described for the preparation of 2-methoxy-6-propionyl-naphthalene, an intermediate in the synthesis of naproxen.
The process consists of Friedel-Crafts acylation of 2-methoxy-naphthalene, and obviates the drawbacks related to the use of nitrobenzene as solvent.

REFERENCES:
patent: 3803245 (1974-04-01), Lodewijk
patent: 4593125 (1986-06-01), Davenport et al.
patent: 4736061 (1988-04-01), Piccolo et al.
patent: 4868338 (1989-09-01), Magni et al.

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