Process for preparing an optically active amine

Details Process for preparing an optically active amine Process for preparing an optically active amine

1996-03-14

1997-11-11

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546150, 546166, 548482, 548490, 564385, 564387, 564392, 564398, 564415, 564448, 564489, C07C20952, C07D21102

Patent

active

056866160

ABSTRACT:
A novel process for preparing an optically active amine by asymmetric hydrogenation of an imine compound, such as an imine compound prepared by condensing benzylamine and acetophenone, in the presence of a catalytic amount of an iridium-optically active phosphine complex and benzylamine or a benzylamine derivative. The present invention provides an optically active amine of high optical purity.

REFERENCES:
patent: 4556740 (1985-12-01), Hansen et al.
patent: 4965348 (1990-10-01), Saulnier et al.
patent: 5047704 (1991-09-01), Yamachi et al.
patent: 5159093 (1992-10-01), Taketomi et al.
patent: 5206399 (1993-04-01), Sayo et al.
patent: 5223632 (1993-06-01), Ishizaki et al.
patent: 5302738 (1994-04-01), Foricher et al.
Chemical Reviews, pp. 1663-1679 (1989).
Asymmetric Catalysis in Organic Synthesis, John Wiley & Sons, Inc. (1994).
James D. Morrison, Asymmetric Synthesis, vol. 5, Academic Press Inc. (1985).
Wagner and Zook, Synthetic Organic Chemistry, Chapter 25--Imines, John Wiley & Sons, Inc., New York; (1953).
Greene and Wuts, Protective Groups in Organic Synthesis, Second Edition, John Wiley & Sons, Inc., New York, pp. 272-275 and 364-369 (1991).
K.N. Campbell, A.H. Sommers and B.K. Campbell, J. Am. Chem. Soc., 66, 82 (1944).
G. Reddelien, Ber. 43, 2476 (1910).
J.H. Billman an and K.M. Tai, J. Org. Chem., 23, 535 (1958).
S.R. Sandler and W. Karo, Organic Functional GroupPreparations, vol. 2, 246, Academic (1971).
S. Dayagi in The Chemistry of the Carbon-Nitrogen Double Bond, ed. By S. Patai, Wiley-Interscience, p. 61 (1970).
H. Takaya et al., J. Org. Chem., vol. 51, 629 (1986).
Chem. Pharm. Bull., p. 1085, vol. 39 (1991).
Synlett, p. 827 (1991).
Tetrahedron: Asymmetry, vol. 3 (1992).
J.L. Herde, J.C. Lambert and C.V. Senoff in Inorg. Synth., 15 (1974).
A. L. Onderdelinden, Inorg. Chim. Acta, 6, 420 (1972).
S.S. Bath and L. Vaska, J. Chem. Soc., 85, 3500 (1963).
M. Green et al., J. Chem. Soc., (A) 2334 (1971).
M.A. Bennett and D.L. Milner, J. Am. Chem. Soc., 91, 6983 (1969).

Affiliated with

Also associated with

Rating

Process for preparing an optically active amine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing an optically active amine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing an optically active amine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1230469