Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-02-02
2010-06-08
Crane, Lawrence E (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S027630, C536S027700
Reexamination Certificate
active
07732595
ABSTRACT:
Disclosed is a synthesis suitable for large scale manufacture of an A2A-adenosine receptor agonist, and also relates to polymorphs of that compound, and to methods of isolating a specific polymorph. The A2A-adenosine receptor agonist has the following formula:This compound is prepared by reacting the ethyl ester with methylamine in a sealed pressure reactor.
REFERENCES:
patent: 6403567 (2002-06-01), Zablocki et al.
patent: 6642210 (2003-11-01), Zablocki et al.
patent: 7183264 (2007-02-01), Zablocki et al.
Niiya K. et al, “2-(N′-Alkylidenehydrazino) Adenosines: Potent and Selective Coronaryvasodilators”,Journal of Medicinal Chemistry, American Chemical Society. Washington, vol. 35, No. 24, 1992, pp. 4557-4561.
Elzein Elfatih
Zablocki Jeff
Crane Lawrence E
Gilead Palo Alto, Inc.
Swiss Tanner, P.C.
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