Process for preparing ampicillin

Details Process for preparing ampicillin Process for preparing ampicillin

1979-08-21

1981-02-03

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

544 16, C07D49912

Patent

active

042487803

ABSTRACT:
A process for preparing ampicillin trihydrate is disclosed which comprises acylating silylated 6-aminopenicillanic acid with D(-)-.alpha.-phenylglycylchloride hydrochloride directly in the silylation reaction mixture in the presence of urea as an acid acceptor, hydrolyzing the reaction product and precipitating ampicillin-trihydrate from the resulting aqueous solution. The amounts of reactants, in particular of solvents and water, are adjusted to provide good yields of a product of high purity.

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patent: 3351597 (1967-11-01), Higgins
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patent: 3741959 (1973-06-01), Looker et al.
patent: 3980637 (1976-09-01), Grossman et al.
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Chemical Abstracts 61:663f, (1964).
Chemical Abstracts 61:1869b, (1964).
Chemical Abstracts 61:4361e, (1964).
Chemical Abstracts 61:4362a, (1964).
Chemical Abstracts 61:8315d, (1964).
Chemical Abstracts 61:13316a, (1964).
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Chemical Abstracts 62:1666e, (1965).
Chemical Abstracts 62:3890f, (1965).
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Chemical Abstracts 63:8386f-8369c, (1965).
Newman et al., Tethedron Letters, No. 34, pp. 3267-3269, (1967).
Merck Index, 8th Edition, Merck & Co., Rahway, N.J., p. 80, (1968).

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