Process for preparing amorphous...

Details Process for preparing amorphous... Process for preparing amorphous...

2011-05-17

2011-05-17

Shiao, Rei-tsang (Department: 1628)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07943786

ABSTRACT:
The invention relates to a process of preparing amorphous (4R-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid-tertiary butyl ester which is a useful pharmaceutical intermediate in the preparation of atorvastatin salts.

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Baumann K L et al: “The convergent synthesis of CI-981, an optically actives, highly potent, tissue selective inhibitor of HMG-COA reductase” Tetrahedron letters, elsevier science publishers, Amsterdamn NL, vol. 33, No. 17, Apr. 21, 1992, pp. 2283-2284, example 7.

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