Process for preparing aminostilbene derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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Reexamination Certificate

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06930205

ABSTRACT:
The present invention relates to a novel process for preparing an aminostilbene derivative, which is important as an active component of anticancer drugs or an intermediate for preparation thereof, as well as methods of producing the same.

REFERENCES:
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patent: 2001/0034454 (2001-10-01), Pinney et al.
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patent: WO 98/39323 (1998-09-01), None
Pinney, K.G., et al., “Synthesis and Biological Evaluation of Aryl Azide Derivatives of Combretastatin A-4 as Molecular Probes for Tubulin,”Bioorganic&Medicinal Chemistry,vol. 8, No. 10, pp. 2417-2425 (2000).
Cushman, Mark, et al., “Synthesis and Evaluation of Stilbene and Dihydrostilbene Derivatives as Potential Anticancer Agents that Inhibit Tubulin Polymerization,”J. Med. Chem.,1991, vol. 34, pp. 2579-2588.
Ohsumi, Koji, et al., “Novel Combretastatin Analogues Effective Against Murine Solid Tumors: Design and Structure—Activity Relationships,”J. Med. Chem.,(1998), vol. 41, pp. 3022-3032.
Gowda, D.C., et al., Catalytic Transfer Hydrogenation of Aromatic Nitro Compounds by Employing Ammonium Formate and 5% Platinum on Carbon,Synthetic Communications,vol. 30, No. 20, pp. 3639-3644 (2000).
Variyar, Prasad S., et al., “Synthesis of 3,4-dihydroxy-6-(N-ethyl-amino)benzamide, a New Phenolic Compound Isolated From Green Pepper”,Indian Journal of Chemistry,vol. 34B, Oct. 1995, pp. 911-913.

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