Process for preparing aminocrotonylamino-substituted...

Details Process for preparing aminocrotonylamino-substituted... Process for preparing aminocrotonylamino-substituted...

2011-06-14

2011-06-14

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

07960546

ABSTRACT:
The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups Ra, Rb, Rcand Rdhave the meanings given in the claims, as well as sulphonyl derivatives of formula (XIII) and the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.

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International Search Report for PCT/EP2007/050752 mailed Jul. 11, 2007.

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