Process for preparing amino-functional cyclodextrin derivative

Details Process for preparing amino-functional cyclodextrin derivative Process for preparing amino-functional cyclodextrin derivative

1994-12-13

1996-07-16

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536107, 536115, 536124, C08B 3716, C07D26324, C07D26352, C07D26510

Patent

active

055368263

ABSTRACT:
A process for preparing amino-functional cyclodextrin derivatives has an amino function which is linked to the cyclodextrin (CD) via a spacer. Compositions containing CD derivatives are prepared by this process. In this process, .alpha.-cyclodextrin, .beta.-cyclodextrin or .gamma.-cyclodextrin, or their partially substituted derivatives, is reacted individually or in arbitrary mixture with at least one cyclic carbamic ester. The CD derivatives, as regards the listed amino substituents, have an average degree of molar substitution per anhydroglucose unit (MS) of 0.01-0.2 and a proportion of monoamino-substituted CD derivatives which is greater than 70%.

REFERENCES:
patent: 3553191 (1971-01-01), Parmerter
patent: 4920214 (1990-04-01), Freidman
patent: 5354852 (1994-10-01), Ikeda
CA 117:92570 "Lower--aminoalkylated cyclodextrin derivatives as color developers for nitrophenols" Yagi, Tatsuhiko: et. al., Jpn Kokai Tokyo Koho, 1992.
B. L. Philips, P.A. Argabright, J. Heterocycl. Chem. 3, 84 (1966).
"Reaction of Inorganic Cyanates with Halides. II. Reactions of Chlorohydrins".
K. Laumen, E. H. Reimerdes, M. Schneider, Tetrahedron Letters 26 (4), 407-410 (1985).
"Immobilized Porcine Liver Esterase: A convenient reagent for the preparation of chiral building blocks".

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