Process for preparing amines

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C564S463000

Reexamination Certificate

active

11079167

ABSTRACT:
A process for preparing an amine which comprises in preparing an amine by decarboxylating an α-amino acid under heating in a high boiling liquid polymer having average molecular weight 200 to 6000, and directly recovering this amine by distillation in the same reaction system, namely in one pot.

REFERENCES:
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patent: 5-255204 (1993-10-01), None
patent: 2001-220372 (2001-08-01), None
patent: 97/43256 (1997-11-01), None
Mehler, T. et al., “Enantioselective addition of diethylzinc to aromatic aldehydes catalysed by chiral ligands derived from L-hydroxyproline”,Synthetic Communications, vol. 23(19), pp. 2691 to 2699 (1993).
Hashimoto, M. et al., “A novel decarboxylation of α-amino acids. A facile method of decarboxylation by the use of 2-cyclohexen-1-one as a catalyst”,Chemistry Letters, pp. 893 to 896 (1986).
Wallbaum, S. et al., “Decarboxylation of α-amino acids containing two and three stereogenic centers: a simple one-step procedure to prepare two optically active β-amino alcohols and a bicyclic pyrrolidine derivative”,Synthetic Communications, vol. 24(10), pp. 1381 to 1387 (1994).
Pandey, G. et al., “Further Evidence on the PET Cyclization of α-Silylmethylamines Tethered with Non-activated Olefins: Demonstration by the Total Synthesis of (-)-Retronecanol.”Tetrahedron Letters, vol. 37, No. 13, pp. 2285 to 2288 (1996).
Trybulski, E. et al., “The synthesis and structure activity relationships of enantiomerically pure hydroxylated oxotremorine derivatives”Bioorganic and Medicinal Chemistry Letters, vol. 2, No. 8, pp. 827 to 832 (1992).

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