Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-05-22
2011-10-18
Chandrakumar, Nizal (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C558S086000
Reexamination Certificate
active
08039628
ABSTRACT:
The present invention relates to a process for isolating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.
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Imhof, R. et al., “Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.”, Journal of Medicinal Chemistry, Feb. 1984, pp. 165-175, vol. 27, No. 2, (XP002373516).
Jacques, J. et al., “Enantiomeric Cyclic Binaphthyl Phosphoric Acids as Resolving Agents”, Tetrahedron Letters, 1971, pp. 4617-4620, vol. 48, (XP002373514).
Periasamy M., “Novel Methods of Resolving Raemic Diol and Amino Alcohols”, Aldrichimica Acta, Aldrich Chemical Co., Milwaukee, US, 2002, pp. 89-101, vol. 35, No. 3, (XP002373517).
Tamai, Y., et al., “A Practical Method for Resolution of the Optical Isomers of 2,2′-Dihydroxy-1,1′-binaphthalene”, 1990, Synthesis, Georg Thieme Verlag, Stuttgart, De, pp. 222-223 (XP002373515).
Bader Thomas
Horns Stefan
Porstmann Frank Ralf
Chandrakumar Nizal
Dodd Thomas J.
Janssen Pharmaceutica N.V.
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