Process for preparing .alpha.-hydroxy-acids and compounds obtain

Details Process for preparing .alpha.-hydroxy-acids and compounds obtain Process for preparing .alpha.-hydroxy-acids and compounds obtain

1985-11-21

1987-06-23

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562421, 549473, 549469, 549 32, 548562, 548502, C07C 5142, C07D33324

Patent

active

046754199

ABSTRACT:
The invention relates to a process for preparing .alpha.-hydroxy-acids of general formula: ##STR1## in which R represents hydrogen or a lower alkyl radical and Cy represents a phenyl, naphthyl or heterocyclic radical, these latter three radicals optionally comprising one or more substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy radicals and halogen atoms, process which comprises the treatment of an .alpha.-monohalogenated ketone of general formula: ##STR2## in which R and Cy have the same meaning as above and X represents chlorine, bromine or iodine, in the presence of an aqueous solution of an alkali metal hydroxide, a non-polar organic solvent selected from an aromatic or alicyclic hydrocarbon and oxygen in excess optionally in the presence of an inert gas, the treatment being carried out at a temperature ranging from the boiling temperature of the reaction medium at atmospheric pressure and 240.degree. C. under pressure and the alkali metal so formed is then acidified to obtain the desired acid.

REFERENCES:
patent: 4219659 (1980-08-01), Fujisawa
patent: 4266067 (1981-05-01), Fujisawa
Hilgerag Preparative Org. Chem. 1972, p. 341.

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