Process for preparing alpha (alkyl phenyl)-4(hydroxy-diphenylmet

Details Process for preparing alpha (alkyl phenyl)-4(hydroxy-diphenylmet Process for preparing alpha (alkyl phenyl)-4(hydroxy-diphenylmet

1989-09-22

1992-05-12

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

346241, C07D21122

Patent

active

051129787

ABSTRACT:
A process for preparing alpha-(alkylphenyl)-4-(hydroxy diphenylmethyl)-1-piperidine butanols of formula (I) ##STR1## in which R is a C.sub.1 -C.sub.5 alkyl, by reacting an isonipecotate of formula (II): ##STR2## in which R' is a C.sub.1 -C.sub.5 alkyl or benzyl, with 1-(alkylphenyl)-4-chlorobutanol to obtain the compound (IV) directly ##STR3## and reacting (IV) with phenylmagnesium halide (V) to obtain (I).

REFERENCES:
patent: 4673683 (1987-06-01), Buschmann et al.
Chemical Abstracts, 107:23250y Abstract of Spanish Patent ES 522, 610, published Sep. 16, 1984 (1987).

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