Process for preparing adenine

Details Process for preparing adenine Process for preparing adenine

1989-03-15

1991-03-05

Rivers, Diana G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

534582, 534739, C07D47334

Patent

active

049979396

ABSTRACT:
A process for preparing adenine by reacting an arylazomalononitrile with formic acid or its derivatives in the presence of ammonia and then subjecting the intermediate pyrimidine derivative to a reaction under catalytic reduction condition. Adenine can be prepared in high purity and high yields without isolating the intermediate pyrimidine derivative, when ammonia is removed before conducting the reaction under catalytic reduction condition. Also, the preparation of adenine in high purity and high yields can be more surely attained, when the arylazomalononitrile prepared under a specific condition is employed as a starting material or when Raney nickel is employed as a reduction catalyst in combination with active carbon. The produced adenine is effectively purified by separation of insoluble materials from an aqueous hot solution of adenine adjusted to pH 7.5 to 9.0 and formation of a mineral acid salt of adenine followed by decoloration by heating in the presence of active carbon.

REFERENCES:
patent: 2658889 (1953-11-01), Goldberg et al.
patent: 3213124 (1965-10-01), Sheppard
patent: 3382228 (1968-05-01), Ferrari et al.
patent: 4092314 (1978-05-01), van der Zwan
Kirk-Othmer, Encyclopedia of Chemical Technology, 2nd, ed., vol. 4, p. 156 (1964).

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