Process for preparing acylaromatic compounds

Details Process for preparing acylaromatic compounds Process for preparing acylaromatic compounds

1998-11-12

1999-10-05

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

564344, 564343, C07C22100, C07C 4500

Patent

active

059627433

ABSTRACT:
This invention provides a process for preparing acylaromatics comprising reacting an aromatic compound with a carboxylic acid in the presence of a reaction medium comprising polyphosphoric acid and a strong protic acid. In one embodiment, the invention provides a process for preparing a para-acyl phenoxyethylamine comprising the steps of reacting a 2-phenoxyethyl compound bearing a leaving group on the ethyl 1-position with a carboxylic acid in the presence of a reaction medium comprising polyphosphoric acid and a strong protic acid, to form apara-acyl phenoxyethyl intermediate bearing the leaving group; and reacting the para-acyl phenoxyethyl intermediate with an amine that substitutes for the leaving group to form the para-acyl phenoxyethylamine.

REFERENCES:
patent: 2475564 (1949-07-01), Hartough et al.
patent: 4599452 (1986-07-01), Colquhoun et al.
patent: 5041616 (1991-08-01), Sumner
patent: 5235068 (1993-08-01), Minwi et al.
patent: 5347047 (1994-09-01), Siegel et al.
patent: 5434310 (1995-07-01), Waldmann et al.
patent: 5621146 (1997-04-01), Fukumoto

Affiliated with

Also associated with

Rating

Process for preparing acylaromatic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing acylaromatic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing acylaromatic compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1173576