Process for preparing acid salts of Gemifloxacin

Details Process for preparing acid salts of Gemifloxacin Process for preparing acid salts of Gemifloxacin

2008-04-22

2008-04-22

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07361762

ABSTRACT:
The present invention relates to a process for preparing acid salts of Gemifloxacin, a quinolone type antibiotic agent having potent antimicrobial activity. The process according to the present invention can provide advantages such as simplicity of process, improvement of productivity and improvement of yield, and the like by reducing conventional three-step process to two-step process.

REFERENCES:
patent: 5633262 (1997-05-01), Hong et al.
patent: 5776944 (1998-07-01), Hong et al.
patent: 5869670 (1999-02-01), Hong et al.
patent: 5962468 (1999-10-01), Hong et al.
patent: 6307059 (2001-10-01), Chang et al.
patent: 0 058 614 (1982-08-01), None
patent: 0 266 576 (1988-05-01), None
patent: 0 183 129 (1989-08-01), None
patent: 0 326 891 (1989-08-01), None
patent: 0 541 086 (1993-05-01), None
patent: 0 688 772 (1995-12-01), None
patent: 0 805 156 (1997-11-01), None
patent: 0 688 772 (1999-05-01), None
patent: 1-100165 (1989-04-01), None
patent: 3-56479 (1991-03-01), None
patent: 6-73056 (1994-03-01), None
patent: WO-91/02526 (1991-03-01), None
patent: WO-92/10191 (1992-06-01), None
patent: WO-96/39406 (1996-12-01), None
patent: WO-97/07098 (1997-02-01), None
patent: WO-97/36874 (1997-10-01), None
patent: WO-98/42705 (1998-10-01), None
patent: WO-99/44991 (1999-09-01), None
patent: WO-99/61420 (1999-12-01), None
patent: WO-00/17199 (2000-03-01), None
patent: WO-01/00209 (2001-01-01), None
patent: WO-01/15695 (2001-03-01), None
patent: WO-01/17961 (2001-03-01), None
patent: WO-01/18002 (2001-03-01), None
patent: WO-01/21176 (2001-03-01), None
patent: WO-01/68649 (2001-09-01), None
patent: WO-02/18336 (2002-03-01), None
Alex R. Khomutov, Alexander S. Shvetsonv, Jouko J. Vesalainen and Anatoly M. Kritzyn, Novel acid-free cleavage of N-(2-hyroxyaryliene) protected amines, Tetrahedron Letters 42:2887-2889 (2001).
Chang Yong Hong, Young Kwan Kim, Yong Hee Lee, and Jin Hwan Kwak, Methyloxime-Substituted Aminopyrrolidine: A new Surrogate for 7-Basic Group of Quinolone, Bioorganic & Medicinal chemistry Letters 8:221-226 (1998).
P. Bey and J.P. Vevert, Synthesis of alpha-Alkyl and alpha-Functionalized Methyl-alpha-Amino Acids, Tetrahedron Letters 17:1455-1458 (1977).
Martin J. O'Donnell, James M. Boniece adn Samuel E. Earp, The Synthesis of Amino Acids by Phase-Transfer Reactions, Tetrahedron Letters 30:2641-2644 (1978).
Khomutov et al., Novel Acid-Free Cleavage of N-(2-hydroxyarylidiene) protected amines, Tetrahedron Lett., 42:2887-2889 (2001).
A. Graul et al., “Fluoronaphthyridinecarboxylic Acid Antibacterial; In Drugs of the Future”, (1998), 23(11), 1199-1204.

Affiliated with

Also associated with

Rating

Process for preparing acid salts of Gemifloxacin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing acid salts of Gemifloxacin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing acid salts of Gemifloxacin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2760021