Process for preparing a trifluoroethoxy-substituted benzoic...

Details Process for preparing a trifluoroethoxy-substituted benzoic... Process for preparing a trifluoroethoxy-substituted benzoic...

2005-02-01

2005-02-01

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S476000, C562S478000

Reexamination Certificate

active

06849762

ABSTRACT:
The invention relates to a method for the production of trifluoroethoxy-substituted benzoic acids, by reaction of a corresponding halogenated benzoic acid with trifluoroethanol in the solvent tetrahydrofuran, in the presence of a base and a copper salt, followed by an acidic work-up.

REFERENCES:
patent: 3931954 (1990-03-01), None
patent: WO 9847853 (1998-10-01), None
Jay Wrobel et al., “Syntheses of Tolrestat Analogues Containing Additional Substituents in the Ring and Their Evaluation as Aldose Reductase Inhibitors. Identification of Potent, Orally Active 2-Fluoro Derivatives”, J. Med. Chem. 1991, 34, pp. 2504-2520.
Search Report for International Application No. PCT/EP01/05923 dated Feb. 5, 2002.

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