Process for preparing a sulfonated chitosan

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 553, C08B 3708, C07H 506, A61K 3173

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active

052295044

ABSTRACT:
There is disclosed a process for preparing a sulfonated chitosan wherein C3/C6-position hydroxyl groups are selectively sulfonated with inexpensive sulfonating agents which comprises dissolving or swelling chitosan in an acetic acid in water, regenerating chitosan with an alkaline aqueous solution, washing the regenerated chitosan with water and then with alcohol, immersing the chitosan in a polar solvent and pressing the solvent out of the same and sulfonating the chitosan with SO.sub.3 -DMF complex or ClHSO.sub.3an -DMF complex in a non-polar solvent. Separation of the product can be easily effected by way of filtration and the like.

REFERENCES:
patent: 4810695 (1989-03-01), Conti et al.
patent: 5021561 (1991-06-01), Butelman
Chemical Abstracts, vol. 114, No. 4, issued 1991, Jan. 28 (Columbus, Ohio, U.S.A.) Fujita et al `Sulfonated Porous Particulate Chitosan Derivatives` see p. 107, column 2, the abstract No. 26071w, Jpn. Kokai Tokkyo Zkoho JP 02,229,832 [90,229,832] 12 Sep. 1990, Appl. 89/51,091, 03 Mar. 1989; 6 pp.

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