Process for preparing a sterile, dry crosslinking agent

Details Process for preparing a sterile, dry crosslinking agent Process for preparing a sterile, dry crosslinking agent

1995-06-30

1997-07-01

Nutter, Nathan M.

Liquid purification or separation

Processes

Utilizing electrical or wave energy directly applied to...

250432R, 2504921, 2504923, 378 64, 378 66, 422 22, B01J 1908, A01N 102, A61F 200

Patent

active

056434642

ABSTRACT:
The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.

REFERENCES:
patent: 4865602 (1989-09-01), Smestad et al.
patent: 5162430 (1992-11-01), Rhee et al.
patent: 5292802 (1994-03-01), Rhee et al.
patent: 5306500 (1994-04-01), Rhee et al.
patent: 5328955 (1994-07-01), Rhee et al.

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