Process for preparing a stable, low K-value, water-soluble PVP-i

Details Process for preparing a stable, low K-value, water-soluble PVP-i Process for preparing a stable, low K-value, water-soluble PVP-i

1991-10-08

1992-10-27

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Nitrogen heterocycle

424667, A61K 3174, A61K 3336

Patent

active

051587688

ABSTRACT:
A method of preparing a stable, low K-value, water-soluble polyvinylpyrrolidone-iodine product in the form of a uniform, free-flowing powder which comprises mixing a given amount of water-soluble polyvinylpyrrolidone polymer having a K-value of about 10-20 and about 10-20% by wt. iodine, and about 0.1-0.5% isopropanol, intimately mixing the reactants at room temperature for a sufficient period of time for the iodine to disappear as a separate phase, and then heating the reaction powders while mixing at about 65.degree.-85.degree. C. for a reaction period of at least about 18 hours.

REFERENCES:
World Patent Index 001582432. (Feb. 16, 1976).

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