Process for preparing a solid preparation of a penicillin deriva

Details Process for preparing a solid preparation of a penicillin deriva Process for preparing a solid preparation of a penicillin deriva

1978-11-17

1980-10-07

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424256, C07D49968

Patent

active

042267692

ABSTRACT:
A process for freeze-drying a penicillin derivative of the formula: ##STR1## wherein R is a hydrogen atom or a hydroxyl group, by evaporating a frozen aqueous solution of the penicillin derivative (I) under vacuum from the frozen state to dryness, which is characterized by maintaining the temperature of the frozen solution within a range from the eutectic point of the solution determined by the electric resistance method to -8.degree. C. when the penicillin derivative of the formula (I) wherein R is a hydrogen atom is to be freeze-dried, or -10.degree. C. when the penicillin derivative of the formula (I) wherein R is a hydroxyl group is to be freeze-dried during the primary drying period of the drying process.

REFERENCES:
patent: 3864329 (1975-02-01), Tobiki et al.
patent: 4029804 (1977-06-01), Clark et al.
Remington's Practice of Pharmacy, pp. 155-156 (12th ed., 1961).
Kirk-Othmer, "Encyclopedia of Chemical Technology", vol. 7, pp. 368-370 (2nd ed., 1966).

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