Process for preparing a single enantiomer of a lactam using lact

Details Process for preparing a single enantiomer of a lactam using lact Process for preparing a single enantiomer of a lactam using lact

1993-05-20

1994-02-08

Naff, David M.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C07C 700, C12N 978

Patent

active

052847691

ABSTRACT:
Lactams of 1-amino-3-carboxylic acid cyclic compounds are produced in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides.

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Caamano et al., Heterocycles, "An approach to the enantio selectur Synthesis of 2-Azabicycolo [2.2.1]Hept-5-en-zone," vol. 27, No. 12, 2839-2841, 1988.
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Chemical Abstracts, vol. 91, No. 25, Dec. 17, 1979, p. 25, abstract No. 204205j, Columbus, Ohio; G. A. R. Johnston et al.: "Stereospecific actions of GABA analogs", and ADV Pharmacol Ther., Proc. Int. Congr. Pharmacol, 7th 1978 (Pub. 1979) 2, 11-18.
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