Process for preparing a polyformyl arylamine

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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Reexamination Certificate

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11116255

ABSTRACT:
A process including reacting a substituted or unsubstituted arylamine or a mixture thereof with a Vilsmeier reagent in the presence of a weakly polar liquid.

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Miyake et al., Organic Process Research and Development (2002), 6, p. 922-925.
Downie, Ian M., et al., “Vilsmeier Formylation and Glyoxylation Reactions of Nucleophilic Aromatic Compounds Using Pyrophosphoryl Chloride,”Tetrahedron, 49(19):4015-4034 (1993).
Dyer, Ulrich, C., et al., “Scale-Up of a Vilsmeier Formylation Reaction: Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory,”Organic Process Research&Development, 6:311-316 (2002).
Sayah, Babak et al., “Highly Regioselective Vilsmeier-Haack Acylation of Hexahydropyrroloindolizine,”J. Org. Chem., 66:2522-2525 (2001).

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