Process for preparing a physical form of pharmaceutical agent

Details Process for preparing a physical form of pharmaceutical agent Process for preparing a physical form of pharmaceutical agent

1994-06-17

1995-11-14

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20914

Patent

active

054668263

ABSTRACT:
A physical form of (R)-3-methoxy-4-[1-methyl-5-(2-methyl-4,4,4-trifluorobutylcarbamoyl)indol- 3-ylmethyl]-N-(2-methylphenylsulphonyl)benzamide substantially free of other physical forms, which form is crystalline and has an X-ray powder diffraction pattern with specific peaks at 2.THETA.=14.0.degree., 19.4.degree., 22.0.degree., 22.4.degree. and 24.7.degree., processes for preparing the form and pharmaceutical compositions containing it. The compound is a leukotriene antagonist useful in the treatment of diseases such as asthma.

REFERENCES:
patent: 4918094 (1990-04-01), Bernstein et al.
Grassen, K., "Zun Einfluss Von Trifluoromethylgruppen Auf Die Reaktion Aliphatischer Diazonium Lonen and Carbokationen," Chem. Ber. (1986) 119, 2233-48.

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