Process for preparing a pharmaceutical composition

Details Process for preparing a pharmaceutical composition Process for preparing a pharmaceutical composition

1991-11-12

1995-08-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424423, 424426, 424451, 424497, 424501, 424502, 514800, 514806, 514808, 514963, 930 21, 930130, 930160, A61K 914, A61K 3724, A61K 948

Patent

active

054396883

ABSTRACT:
A pharmaceutical composition is prepared in the form of microparticles or of an implant comprising a biodegradable polymer selected from poly-1,4-butylene succinate, poly-2,3-butylene succinate, poly-1,4-butylene fumarate and poly-2,3-butylene succinate, incorporating as the active substance the pamoate, tannate, stearate or palmitate of a natural or of a synthetic peptide comprising 3 to 45 amino acids, such as LH-RH, somatostatin, GH-RH or calcitonin, or one of their synthetic analogues or homologues. The preparation comprises dry blending the ingredients in the form of powders, pre-compressing and preheating the mixture and then extruding the pre-compressed and pre-heated mixture. The product resulting from the extrusion step can then be comminuted and finally sieved.

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