Process for preparing a neutralized oxidized cellulose product a

Details Process for preparing a neutralized oxidized cellulose product a Process for preparing a neutralized oxidized cellulose product a

1990-12-13

1992-07-28

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424443, 424444, 424446, 424447, 536124, 604292, 606213, 602900, C08B 1502, C08B 2302, A61K 3170

Patent

active

051342294

ABSTRACT:
Oxidized cellulose material is neutralized, by contacting an acidic oxidized cellulose material with a water and alcohol solution of a basic salt of a weak organic acid, e.g. sodium acetate, to elevate the pH of the cellulosic material to between 5 and 8. The resulting neutralized product is storage stable and has therapeutic applications, including hemostasis and adhesion prevention. Furthermore, the neutralized product may be impregnated with acid-sensitive hemostatic agents, such as thrombin, to enhance its hemostatic properties, or with acid-sensitive adhesion-preventive agents, such as t-PA, to enhace its adhesion-prevention properties.

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Dol'berg, E. B., Oridoroga, V. A.; Shuteeva, L. N. Yasnitskii, B. G., Farm. Zh. (Kiev) 1971, 26(2), 5306 (Ukrain).

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