Process for preparing a morphinan derivative

Details Process for preparing a morphinan derivative Process for preparing a morphinan derivative

1997-09-29

1999-06-15

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 14, C07D48900, C07D48912, C07F 702

Patent

active

059123478

ABSTRACT:
A process for preparing a morphinan derivative by providing a dihydrofuranyl bridged tetracycle halide of the formula (19) ##STR1## in which X is halogen, R is an alkyl group of from 1 to about 10 carbon atoms, and R.sub.1 is a protecting group. The pentacycle halide is converted into a morphinan derivative of formula (20) ##STR2## in which R is a previously defined.

REFERENCES:
Kathlyn A. Parker et al., "The Radical Cyclization Approach to Morphine. Models for Highly Oxygenated Ring-III Synthons", J. Org. Chem., vol. 59, No. 14, 1994, pp. 3933-3938.

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