Process for preparing a disaccharide derivative

Details Process for preparing a disaccharide derivative Process for preparing a disaccharide derivative

1990-01-29

1991-11-19

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 53, 536117, 536 41, 536 171, 536 172, C07H 506, C07H 102

Patent

active

050667947

ABSTRACT:
Disaccharide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 CO-- and R.sup.2 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms and having a hydroxyl group at the 3-position thereof; R.sup.3 CO-- and R.sup.4 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms; and m and n each represents an integer of from 8 to 12, and the salts thereof. The compounds exhibit biological activities equal to or higher than those of natural lipid A. Also, the compounds of this invention are very useful as standard reagent for determination of endotoxin in the samples to be tested.

REFERENCES:
patent: 4495346 (1985-01-01), Anderson et al.
Galanos et al.; Chemical Abstracts, vol. 100: 169643f, May 21, 1984.
Imoto et al.; Chemical Abstracts, vol. 100: 82458a, Mar. 12, 1984.
Kanegasaki et al.; Chemical Abstracts, vol. 101: 185675a, Nov. 19, 1984.
Qureshi et al.; Journal of Biological Chemistry, 258(21), 12947-12951, Nov. 10, 1983.
Imoto et al.; Tetrahedron Letters, 25(25): 2667-2670 (1984).
Kusumoto et al.; Tetrahedron Letters, 25(34): 3727-3730 (1984).
Kotani, S. et al.; Infection and Immunity, vol. 49:1 (225-237), Jul. 1985.
Galanos et al.; Eur. J. Biochem, vol. 140(2): 221-227, Apr. 1984.

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