Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2005-03-15
2005-03-15
Spear, James M. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C424S464000, C424S465000, C424S468000, C424S474000, C424S489000
Reexamination Certificate
active
06866867
ABSTRACT:
The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.
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Machines Collette High Shear Mixer Granulator Promotional Literature. (date unknown).
Davidson Clifford M.
Hunter Edward A.
Sherwood Bob E.
Staniforth John N.
Davidson Davidson & Kappel LLC
J. Rettenmaier & Soehne GmbH & Co. KG
Spear James M.
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