Process for preparing a dipeptidyl peptidase IV inhibitor...

Details Process for preparing a dipeptidyl peptidase IV inhibitor... Process for preparing a dipeptidyl peptidase IV inhibitor...

2007-01-30

2008-09-02

Anderson, Rebecca L (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C560S227000

Reexamination Certificate

active

07420063

ABSTRACT:
A process is provided for preparing a dipeptidyl peptidase IV inhibitor of the structureis treated with TFAA in isopropyl acetate to protect the tertiary hydroxyl group as a trifluoroacetate group to form 4(which is a novel intermediate) which is converted to acid chloride compound 5(which is a novel compound) using Vilsmeier reagent or other chloro reaget and coupled with compound 6 in a heterogeneous mixture of ethyl acetate and aqueous bicabonate to give compound 7The N,O-bis(trifluoroacetyl) groups of compound 7 are deprotected to give free base compound 10.

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