Process for preparing a concentrate of blood coagulation factor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530415, 530416, 530417, 530420, A61K 3836, A61K 3837, C07K 130, C07K 136

Patent

active

056797761

ABSTRACT:
The invention relates to a process for preparing a concentrate of Factor VIII-von Willebrand factor complex having high specific activity from total (non-cryoprecipitated) plasma.
The process comprises pre-purifying by means of a double treatment with barium chloride and with aluminium hydroxide.
The process then comprises purification by chromatography on an anion exchange resin, of the DEAE-Fractogel type.
The process includes a step of viral inactivation by means of a treatment with solvent-detergent.
The process also makes it possible to recover fibrinogen, albumin, immunoglobulins, antithrombin III, fibronectin and prothrombin complex, from the same plasma.
The different concentrates obtained using the process according to the invention are intended, in particular, for therapeutic use.

REFERENCES:
patent: 4157431 (1979-06-01), Fields et al.
patent: 4361509 (1982-11-01), Zimmerman et al.
patent: 4386068 (1983-05-01), Mitra et al.
patent: 4435318 (1984-03-01), Pabst et al.
patent: 4952675 (1990-08-01), Mathews et al.
Murray et al. (1988). Harper's Biochemistry. Appleton & Lange, p. 607.
Wang et al. (1988) J. Parenteral Sci. & Tech. vol. 42 (Supp): pp. S1-526.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for preparing a concentrate of blood coagulation factor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing a concentrate of blood coagulation factor , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing a concentrate of blood coagulation factor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1007660

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.