Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1990-09-05
1997-10-21
Hendricks, Keith D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530415, 530416, 530417, 530420, A61K 3836, A61K 3837, C07K 130, C07K 136
Patent
active
056797761
ABSTRACT:
The invention relates to a process for preparing a concentrate of Factor VIII-von Willebrand factor complex having high specific activity from total (non-cryoprecipitated) plasma.
The process comprises pre-purifying by means of a double treatment with barium chloride and with aluminium hydroxide.
The process then comprises purification by chromatography on an anion exchange resin, of the DEAE-Fractogel type.
The process includes a step of viral inactivation by means of a treatment with solvent-detergent.
The process also makes it possible to recover fibrinogen, albumin, immunoglobulins, antithrombin III, fibronectin and prothrombin complex, from the same plasma.
The different concentrates obtained using the process according to the invention are intended, in particular, for therapeutic use.
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patent: 4386068 (1983-05-01), Mitra et al.
patent: 4435318 (1984-03-01), Pabst et al.
patent: 4952675 (1990-08-01), Mathews et al.
Murray et al. (1988). Harper's Biochemistry. Appleton & Lange, p. 607.
Wang et al. (1988) J. Parenteral Sci. & Tech. vol. 42 (Supp): pp. S1-526.
Burnouf Thierry
Burnouf-Radosevich Miryana
Centre Regional de Transfusion Sanguine de Lille
Hendricks Keith D.
Moore W.
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