Process for preparing a 7-aminocephalosporanic acid compound

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-5-aza-bicyclo

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435228, 435874, C12P 3502, C12N 980, C12R 138

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active

047741791

ABSTRACT:
A process for preparing a 7-aminocephalosporanic acid compound which comprises treating a cephalosporin C compound with an enzyme-producing microorganism belonging to the genus Pseudomonas or a material obtained by subjecting the microorganism to chemical and/or physical treatment. A direct hydrolysis of the cephalosporin C compound into the 7-aminocephalosporanic acid compound and D-.alpha.-aminoadipic acid can be attained by the microorganism or material.

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Agric. Biol. Chem., 45(7), 1561-1567, 1981.
Edwin H. Flynn: "Cephalosporins and Penicillins", pp. 37-39, Academ ic Press, New York and London, 1972.
Edwin H. Lennette et al: "Manual of Clinical Microbiology", 3rd Edition, American Soc. for Microbiology, Wash., D.C., 1980.
Noel R. Krieg et al: "Bergey's Manual of Systematic Bacteriology", vol. 1, Williams & Wilkins, Baltimore/ London.

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