Process for preparing a 5-hydroxy-3-oxo-hexanoic acid...

Details Process for preparing a 5-hydroxy-3-oxo-hexanoic acid... Process for preparing a 5-hydroxy-3-oxo-hexanoic acid...

2006-07-25

2006-07-25

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

Reexamination Certificate

active

07081546

ABSTRACT:
The present invention is related to a novel process for preparing an optically active 5-hydroxy-3-oxo-hexanoic acid derivative or its tautomer which is useful intermediate for preparing statins such as atorvastatin and rosuvastatin. Blaise reaction of (S)-4-halo-3-hydroxybutyronitrile with -haloacetate is utilized as a key reaction to provide the product with minimal formation of side products and in good yield.

REFERENCES:
patent: 5594153 (1997-01-01), Thottathil et al.
patent: 6340767 (2002-01-01), Nishiyama et al.
patent: 6399339 (2002-06-01), Wolberg et al.
patent: 1024139 (2000-10-01), None
Scheffler et al., “Preparation and stereoselective hydrogenation of chiral (4-hydroxytetrafuranylidene)carboxylates: a new formal entry to functional anti- and syn-3, 5-dihydroxy esters”Tetrahedron Letters (2002), 43(15), 2679-2682.

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