Process for preparing a 2-methyl-(substituted aryl)-pyruvic acid

Details Process for preparing a 2-methyl-(substituted aryl)-pyruvic acid Process for preparing a 2-methyl-(substituted aryl)-pyruvic acid

1975-07-28

1977-08-16

Myers, Jane S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26034859, 260473R, 260473A, 260515R, 260515A, 260517, 260520R, 260520B, 26034851, C07C 5109, C07C 63333, C07C 6730, C07C 6976

Patent

active

040426173

ABSTRACT:
A process for preparing 3-methyl-3-(substituted aryl)-pyruvic acid compounds by treating a glycidic acid ester compound of the formula, ##STR1## wherein R.sup.1 is a 4-biphenylyl, 4-clyclohexylphenyl, 3-phenoxyphenyl, 4'-fluoro-4-biphenylyl, 2-fluoro-4-biphenylyl or 3-benzoylphenyl group and R.sup.2 is a lower alkyl group or its corresponding free acid with a Lewis acid to form a 2-hydroxy-3-(substituted aryl)-3-butenoic acid ester and treating the resulting ester in an alcohol with an alkali metal alcoholate to form the pyruvic acid compounds. If desired, the pyruvic acid compounds can then be saponified to compounds of the formula, ##STR2## wherein R.sup.1 is as previously defined and which compounds are useful as anti-inflammatory agents.

REFERENCES:
patent: 3048622 (1962-08-01), Stansbury et al.
patent: 3919304 (1975-11-01), Rossi
patent: 3925458 (1975-12-01), Kogure et al.

Affiliated with

Also associated with

Rating

Process for preparing a 2-methyl-(substituted aryl)-pyruvic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing a 2-methyl-(substituted aryl)-pyruvic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing a 2-methyl-(substituted aryl)-pyruvic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-361092