Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)

Details Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)

1996-01-26

1998-05-26

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

C07D47318

Patent

active

057567360

ABSTRACT:
Process for preparing the L-monovaline ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts. The present process provides an N,O-bis-trityl intermediate of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol which allows for mono-esterification by an L-valine derivative. These products are of value as antiviral agents with improved absorption.

REFERENCES:
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E. Jensen et al., Acta. Pharm. Nord. 3(4) 243-247 (1991).
John C. Martin et. al., J. Pharm. Sci. 76(2), pp. 180-184 (1987).
P.C. Maudgal et al., Arch. Ophthalmol. 1984; 102: 140-142.
Leon Colla et. al., J. Med. Chem. 98, 3, 26, 602-604 (1983).
L. M. Beauchamp et. al., Antiviral Chemistry & Chemotherapy (1992), 3 (3), 157-164.

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