Process for preparing a 1,4-dihydropyridine derivative

Details Process for preparing a 1,4-dihydropyridine derivative Process for preparing a 1,4-dihydropyridine derivative

1982-07-27

1984-08-21

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546319, C07D21355

Patent

active

044670931

ABSTRACT:
In the process for preparing 4-(2'-nitrophenyl-2,6-dimethyl)-3,5-dicarbmethoxy-1,4-dihydropyridine of the formula ##STR1## 2-nitrobenzaldehyd-diacetate, methyl acetoacetate and ammonia are reacted in the presence of an inert organic solvent, such as methanol, and in the presence or absence of an organic base, such as pyridine, at a temperature of between 20.degree. and 150.degree. C. The compound is a valuable medicine for the treatment of angina pectoris.

REFERENCES:
patent: 3485847 (1969-12-01), Bossert et al.
patent: 3644627 (1972-02-01), Bossert et al.
patent: 4297519 (1981-10-01), Ertel
Barton et al., Comprehensive Organic Chemistry, vol. I, pp. 1108-1110, Pergamon Press, (1979).
Hendrickson et al., Organic Chemistry, Third Edition, pp. 90-98, 453-456, and 963, McGraw Hill-Kogakusha Ltd. Pub., (1970).
Bossert et al., Chemical Abstracts, vol. 70, No. 21, 96, 641d, May 26, 1969.
McOmie, Protective Groups in Organic Chemistry, pp. 327-331, Plenum Publishing Corp., 1973.
The Merck Index, Ninth Edition, p. ONR-40, Merck & Co., Inc., pub. 1976.

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