Process for preparing 7-aminocephalosporins

Details Process for preparing 7-aminocephalosporins Process for preparing 7-aminocephalosporins

1978-12-05

1981-08-25

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 26, 544 30, 424246, C07D50104

Patent

active

042860881

ABSTRACT:
7-Aminocephalosporin of the formula: ##STR1## wherein R.sup.2 is 3-oxobutyryloxy group, 1-methyl-1H-tetrazol-5-ylthio group or 1-(2-dimethylaminoethyl)-1H-tetrazol-5-ylthio group, or its salt is prepared by first protecting the carboxyl group at 4-position of the compound of the formula: ##STR2## wherein R.sup.1 is an amino group which may be protected and R.sup.2 is the same as defined above, or its salt with an acetyl or propionyl halide, then cleaving the amide group at 7-position of said compound by converting the amide bond to an imino halide, then to an imino ether and subjecting the imino ether to solvolysis.

REFERENCES:
patent: 3839328 (1974-10-01), Chauvette
patent: 3931161 (1976-01-01), Buitar et al.
patent: 3932392 (1976-01-01), Johnson et al.
patent: 4036833 (1977-01-01), Ishimaru et al.

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