Process for preparing 6(R)-{2-8'(S)-2",2"-dimethylbutyryloxy-2'(

Details Process for preparing 6(R)-{2-8'(S)-2",2"-dimethylbutyryloxy-2'( Process for preparing 6(R)-{2-8'(S)-2",2"-dimethylbutyryloxy-2'(

1998-06-29

1999-12-14

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30930

Patent

active

060020210

ABSTRACT:
An acylation process using a sulfonic acid, a salt of the sulfonic acid, or a mixture thereof, as a catalyst. Compound 6 is prepared by protecting the 4-hydroxyl group on the pyranone ring of the 8'-hydroxy compound 2 to form a .beta.-protected compound 3, acylating the 8-hydroxy group on the polyhydronaphthyl ring of compound 3 to give protected ester, compound 4, then removing the protecting group, where the compounds 6, 2, 3 and 4 are as described in the specification.

REFERENCES:
patent: 4857547 (1989-08-01), Hoffman et al.
patent: 4970231 (1990-11-01), Lee et al.
patent: 5159104 (1992-10-01), Dabora et al.

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