Process for preparing 6(R)-2 (8-hydroxy-2,6-dimethyl-polyhydro-n

Details Process for preparing 6(R)-2 (8-hydroxy-2,6-dimethyl-polyhydro-n Process for preparing 6(R)-2 (8-hydroxy-2,6-dimethyl-polyhydro-n

1998-06-29

1999-11-30

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30930

Patent

active

059945664

ABSTRACT:
The process for preparing compound 2 by reacting the compound 1, each as described in the specification hereof, with a tetraalkyl ammonium hydroxide having the formula R.sub.1 R.sub.2 R.sub.3 R.sub.4 N.sup.+ OH.sup.-, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.10 alkyl group or a (C.sub.6 -C.sub.10) aryl (C.sub.1 -C.sub.10) alkyl group, to obtain an triol carboxylate thereof, acidifying the triol carboxylate, then lactonizing the product to obtain diol lactone, a key intermediate for production of antihypercholesterolemia agents.

REFERENCES:
patent: 4293496 (1981-10-01), Williard
patent: 4444784 (1984-04-01), Hoffman et al.

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