Process for preparing 6,7-benzomorphans

Details Process for preparing 6,7-benzomorphans Process for preparing 6,7-benzomorphans

1976-02-17

1978-12-05

Jiles, Henry R.

Harness for working animal

2603459R, 260556AR, 2605705R, 2605705CA, 546 97, 542430, C07D22126

Patent

active

041285484

ABSTRACT:
The invention is concerned with certain novel 6,7-benzomorphan derivatives having analgesic and/or morphine-antagonistic properties of the formula ##STR1## wherein each R is a lower alkyl group; R.sub.1 is a hydrogen atom, or an alkyl, haloalkyl, alkenyl, haloalkenyl, alkinyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, cycloalkylidenealkyl, aralkyl, heteroarylalkyl or heterocycloalkylalkyl group; R.sub.2 is a hydrogen atom or a hydroxy, alkoxy, alkoxyalkoxy or acyloxy group.
Such 6,7-benzomorphans may be in the form of their optically active enantiomers and/or their therapeutically acceptable salts. Methods for producing such 6,7-benzomorphan derivatives, and novel intermediates useful for such production are also disclosed and form part of the invention.

REFERENCES:
patent: 3138603 (1964-06-01), May
patent: 3372165 (1968-03-01), Archer
patent: 3764606 (1973-10-01), Akkerman et al.
patent: 3969468 (1976-07-01), Tamaki et al.
Sethna, S. in Olah, G., Friedel-Crafts and Related Reactions, vol. III, Part II, Interscience, New York, 1964, pp. 911-915.
Morrison, R., et al., Organic Chemistry, Allyn and Bacon, Inc., Boston, 1959, pp. 417-418.

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