Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone

Details Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone

1983-06-14

1985-07-09

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

562463, C07D23708, C07C 5948

Patent

active

045283710

ABSTRACT:
A process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone which comprises reacting 2-hydroxyacetophenone with glyoxylic acid under alkaline conditions, adjusting the pH of the reaction mixture to give a mixture within a pH range of about pH 4.0-9.5 and which contains a weak base, and subsequently reacting with hydrazine.
6-(2-Hydroxyphenyl)-3-pyridazinone is a useful intermediate in the preparation of anti-hypertensive agents.

REFERENCES:
patent: 4053601 (1977-10-01), Coates et al.
patent: 4111936 (1978-09-01), Coates et al.
patent: 4152517 (1979-05-01), Levinson et al.
Wermuth et al, Chim. Ther., vol. 5(2), (1970), pp. 141-145.
Pettit et al, J. Org. Chem., vol. 35(5), (1970), pp. 1367-1376.
Derwent Abstract 80380Y, (Abstract of Japanese Patent J5 2116-485).
Hasegawa et al, Chem. Pharm. Bulletin, 25:192-195, (1977).
Fieser et al, "Reagents for Organic Synthesis", vol. 1, p. 441, (John Wiley & Sons, New York).

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