Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-10-22
2009-08-18
Andres, Janet L. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S156000
Reexamination Certificate
active
07576214
ABSTRACT:
Starting from ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxo-propanoate (1), the present invention provides highly pure 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (5) in one-pot four steps using a single solvent.
REFERENCES:
patent: 6699989 (2004-03-01), Shetty
patent: 0 160 578 (1985-11-01), None
patent: 3-74231 (1991-03-01), None
patent: 2002-155081 (2002-05-01), None
patent: WO-89/06649 (1989-07-01), None
DN 106:18399, Chu et al abstract (1986).
DN 104:129888, Narita et al abstract (1985).
DN 128:321632, Antons et al abstract (1997).
Nishimura et al., ‘An intramolecular cyclization of 7-substituted 6-fluoro-1,8-naphthyridine and -quinoline derivatives [1] [2]’, J. Heterocyclic Chem. Mar.-Apr. 1988, vol. 25, pp. 479-485.
Sanchez et al., ‘An efficient synthesis of 6-fluoronalidixic acid and its cinversion to enoxacin’, J. Heterocyclic Chem. Jan.-Feb. 1987, vol. 24, pp. 215-217.
Egawa et al., ‘Pyridonecarboxylic acids as antibacterial agents. 4. Synthesis and antibacterial activity of 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and its analogues’, J. Med. Chem., 1984, vol. 27, pp. 1543-1548.
Matsumoto et al., ‘Pyridonecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agent’, J. Med. Chem.
Chang Jay-Hyok
Lee Kyu-Woong
Shin Hyun-Ik
Andres Janet L.
Birch & Stewart Kolasch & Birch, LLP
Covington Raymond
LG Life Sciences Ltd.
LandOfFree
Process for preparing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4085339