Process for preparing 5 pyridyl pyridine-2 (1H)-ones

Details Process for preparing 5 pyridyl pyridine-2 (1H)-ones Process for preparing 5 pyridyl pyridine-2 (1H)-ones

1984-04-19

1986-01-07

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546297, 546264, 546288, C07D40104

Patent

active

045635285

ABSTRACT:
5-Pyridinyl-6-R.sub.2 -3-R.sub.1 -2(1H)-pyridinones (I), where R.sub.2 is hydrogen or lower alkyl and R.sub.1 is a cyano, a carbamoyl or an amino group are prepared: by reaction of 1-R.sub.2 -1-oxo-2-pyridinyl-3-dialkylaminopropane (II) with malonamide under solid-liquid or liquid-liquid phase transfer catalysis conditions to obtain 1,2-dihydro-2-oxo-6-R.sub.2 -5-pyridinylnicotinamide (IV), or by reaction of II with cyanoacetamide under solid-liquid or liquid-liquid phase transfer catalysis conditions to obtain 1,2-dihydro-2-oxo-6-R.sub.2 -5-pyridinylnicotinonitrile (III) and partially hydrolizing III to yield IV; finally the carbamoyl group of IV is converted to amino and 1,2-dihydro-2-oxo-6-R.sub.2 -5-pyridinyl-3-aminopyridin-2-one are obtained.

REFERENCES:
patent: 4107315 (1978-08-01), Lesher et al.

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