Process for preparing 5-halopyrimidines

Details Process for preparing 5-halopyrimidines Process for preparing 5-halopyrimidines

1979-11-02

1981-02-24

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23930

Patent

active

042529557

ABSTRACT:
The reaction of formamide at high temperature with a 4-halo-5-hydroxy-2(5H)-furanone provides high yields of 5-chloro or 5-bromopyrimidines.

REFERENCES:
patent: 3824292 (1974-07-01), Kirby
Bredereck et al., Chem. Ber., 95 803-809 (1962).
Budesinsky, Coll. Czech. Chem. Comm. 14, 223-235 (1949).
McOmie et al., J. Chem. Soc. pp. 3129-3131 (1953).
Yanagita et al., J. Pharm. Soc. Japan 71, 39-40 (1951).
Yanagita, J. Pharm. Soc. Japan 72, 1383-1384 (1952).
Bredereck et al., Ber., 90 942-952 (1957).

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