Process for preparing 5-chloro-4-hydroxypyrimidines

Details Process for preparing 5-chloro-4-hydroxypyrimidines Process for preparing 5-chloro-4-hydroxypyrimidines

1994-07-07

1996-06-04

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544334, C07D23930, C07D23934

Patent

active

055234046

ABSTRACT:
A process for preparing 5-chloro-4-hydroxypyrimidines, 2-chloro enamines as intermediates in this process and their use The invention relates to a process for preparing compounds of the formula ##STR1## in which R.sup.1 is optionally substituted alkyl, cycloalkyl, aryl or benzyl, in which a chloroacetic ester is converted with ammonia or an ammonium salt into the corresponding chloro enamine and the latter is condensed in the presence of a base with formamide. The invention furthermore relates to 2-chloro enamines as intermediates in the process.

REFERENCES:
patent: 4199600 (1980-04-01), Brandman et al.
Chemical Abstracts, 109(9): 73464h, Wenger et al (1988).
Beilstein, 1811955 Abstract of Genvresse, Ann. Chim. (Paris) vol. 24, p. 64 (1891).
Chemical Abstracts, 93(7): 63604r Brandman et al (1980).
Chemical Abstracts, 82(5): 31347r, Bertin et al (1974).

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