Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine

Details Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine

2005-08-23

2005-08-23

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S428000

Reexamination Certificate

active

06933410

ABSTRACT:
A process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine and acid addition salts thereof from 2-aminoindan. The process comprises protecting the amino group of 2-aminoindan, acetylating the ring in the protected compound, reducing the acetyl group to ethyl to form a monoethyl derivative, acetylating the monoethyl derivative, reducing the acetyl group to form a diethyl derivative, deprotecting the latter by hydrolysis and recovering the product in free or salt form. The process does not use deleterious Grignard reagents or nitrites such as isoamyl nitrite, and provides high regioselectivity and high yield of 5,6-diethyl-2,3-dihydro-1H-inden-2-amine. In addition, the process uses acetyl halide as both a reactant and a solvent.

REFERENCES:
patent: 4820705 (1989-04-01), Nickl et al.
patent: 0 253 321 (1988-01-01), None
patent: 1 018 514 (2000-07-01), None
patent: 00/75114 (2000-12-01), None

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