Process for preparing 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothien

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D49504

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047300493

ABSTRACT:
An improved process for the preparation of 5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine and acid addition salts thereof, which are useful as a medicine. This process comprises effecting reaction between 4,5,6,7-tetrahydrothieno[3,2-c]pyridine and 2-chlorobenzyl halide in the presence of a phase transfer catalyst.

REFERENCES:
Maffrand et al., Eur. J. Med. Chem., Chimica Therapeutica, vol. 9(5), pp. 483-486 (1974).
Dehmlow et al., Phase Transfer Catalysis, Verlag Chemie, pp. 1-6 and 93-99 (1980).

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