Process for preparing 5,11-diazatetracyclododecanes

Details Process for preparing 5,11-diazatetracyclododecanes Process for preparing 5,11-diazatetracyclododecanes

1977-03-24

1978-01-24

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260297R, C07D48708

Patent

active

040703592

ABSTRACT:
A new heterocycle, 5,11-diazatetracyclo]6.2.2.0.sup.2,7.0.sup.4,9 ]dodecane, is prepared by heating an endo-diazatricyclo[6.2.2.0.sup.2,7 ]dodec-11-ene substituted in the 7 and 11 positions with electron withdrawing groups. 2,9-Bis-phenylacetyl derivatives of the new heterocycle and closely related derivatives are potent analgesic agents.

REFERENCES:
liberatore, F. et al., Tett. Lett. No. 26, 2381-2384 (1971).
Hirao et al., J. Chem. Soc. Chem. Comm., 691-692 (1974).

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