Process for preparing...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitriles

Reexamination Certificate

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Reexamination Certificate

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06894184

ABSTRACT:
A process is described for producing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamide, in which a phenyl-substituted 2-cyano-N-(phenyl)acetamide is reacted in the presence of a base, acetic anhydride and at least one solvent, and the resultant 2-cyano-3-hydroxy-N-(phenyl-derivative)but-2-enamide is crystallized by acidification.

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patent: 5679709 (1997-10-01), Bartlett et al.
patent: 5700822 (1997-12-01), Hirth et al.
patent: 6121316 (2000-09-01), Schwab et al.
patent: 0257882 (1988-03-01), None
Ghosh, et al., Three leflunomide metabolite analogs, Acta Crystallogr. Sect. C Cryst. Struct. Commun.; 56:10; 2000; pp. 1254-1257.
Veb Deutscher, Umsetzung von Carbonsaurechloriden und -anhydriden, Organikum; 12 Auflage; 1973; p. 525.

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