Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1996-06-18
1998-03-03
Bernhardt, Emily
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544360, C07D24104
Patent
active
057236151
ABSTRACT:
An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butyl-carboxamide, an intermediate for an HIV protease inhibitor.
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Armstrong, et al., Tetrahedron Letters, 1994, 35(20):3239-3242.
Rossen et al, Tet. Lett. vol. 36, pp. 6419-6422 (Sep. 4, 1995).
Kanozia et al, Chemical Abstracts vol. 125, No. 142774 91996) (Abstract for DE 4446025, Jun. 27, 1996).
Landau et al, Journal of Catalysis 157 pp. 201-208 (1995).
Askin David
Reider Paul J.
Rossen Kai
Sager Jess
Volante Ralph P.
Appollina Mary A.
Bernhardt Emily
Merck & Co. , Inc.
Tribble Jack L.
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